Cellular reprogramming via transcription factors is one of the most promising avenues towards lifespan extension. If you can reset your cells back in time, then your tissue function and health can improve.
Janine, one of my co-founders at Junevity, and I wrote a perspective in GEN about why transcription factors, once dismissed as “undruggable” and “too risky,” are now within reach.
The article traces how advances in siRNA, omics, and AI/ML are converging to unlock transcription factors as one of the most powerful and overlooked target classes in medicine.
Resetting transcription factors could lead to a wave of FDA approvals, give new hope for treating our biggest diseases, and open the door to extending healthspan and lifespan.
Read here: https://www.genengnews.com/topics/drug-discovery/unlocking-the-potential-of-transcription-factors/